Laboratory of Alexander Nikitin
  Home People Research Publications Mouse Pathology Alumni Jobs  
Select Publications

 

  • Nikitin, A. Yu., Ballering, L. A. P., Lyons, J., and Rajewsky, M. F. (1991). Early mutation of the neu (erb B-2) gene during ethylnitrosourea-induced oncogenesis in the rat Schwann cell lineage. Proc. Natl. Acad. Sci. USA 88: 9939-9943.
  • Nikitin, A. Yu., Lennartz, K., Pozharisski, K. M., and Rajewsky M. F. (1991). Rat model of the human "Triton" tumor: direct genetic evidence for the myogenic differentiation capacity of schwannoma cells using the mutant neu gene as a cell lineage marker. Differentiation 48: 33-42.
  • Nikitin, A. Yu., Rajewsky, M. F., and Pozharisski, K. M. (1993). Development of malignant fibrous histiocytoma induced by 7,12-dimethylbenz [a] anthracene in the rat: Characterization of early atypical cells. Virchows Arch. [B]. 64:151-159.
  • Nikitin, A. Yu., Jin, J.-J., Papewalis, J., Prokopenko, S. N., Pozharisski, K. M., Winterhager, E., Flesken-Nikitin, A., and Rajewsky, M. F. (1996). Wild-type neu transgene counteracts mutant homologue in malignant transformation of rat Schwann cells. Oncogene, 12: 1309-1317.
  • Nikitin, A. Yu., and Lee, W.-H. (1996). Early loss of the retinoblastoma gene is associated with impaired growth inhibitory innervation during melanotroph carcinogenesis in Rb+/- mice. Genes Devel., 10: 1870-1879.
  • Riley, D. J., Nikitin, A. Yu., and Lee, W.-H. (1996). Adenovirus-mediated, retinoblastoma gene therapy suppresses spontaneous pituitary melanotroph tumors in Rb+/- mice. Nature Medicine, 2: 1316-1321.
  • Nikitin, A. Yu., Riley, D. J., and Lee, W.-H. (1997). Earlier onset of melanotroph carcinogenesis in mice with inherited mutant paternal allele of the retinoblastoma gene. Cancer Res., 57:4274-4278.
  • Nikitin, A. Yu., Juárez-Pérez. M. I., Li, S., Huang, L., and Lee W.-H. (1999). RB-mediated suppression of spontaneous multiple neuroendocrine neoplasia and lung metastases in Rb+/- mice. Proc. Natl. Acad. Sci. USA, 96: 3916-3921.
  • Utomo, A. R. H., Nikitin, A. Yu., and Lee W.-H. (1999). Temporal, spatial, and cell type-specific control of Cre-mediated DNA recombination in transgenic mice. Nature Biotechnology, 17: 1091-1096.
  • Nikitin, A. Yu., Riley, D. J., and Lee W.-H. (1999). A paradigm for cancer treatment using the retinoblastoma gene in a mouse model. Ann. NY Acad. Sci., 886: 12-22.
  • Nikitin, A. Yu., Shan, B., Flesken-Nikitin, A., Chang, K.-H., and Lee, W.-H. (2001). The retinoblastoma gene regulates somatic growth during mouse development. Cancer Res. 61: 3110-3118.
  • Nikitin, A. Yu., Liu, C.-Y., Flesken-Nikitin, A., Chen, C.-F., Chen, P.-L., and Lee, W.-H. (2002). Cell lineage-specific effects associated with multiple deficiencies of tumor susceptibility genes in Msh2-/-Rb+/- mice. Cancer Res., 62: 5134-5138.
  • Tsai, K. Y., MacPherson, D., Rubinson, D., A., Nikitin, A. Yu., Bronson, R., Mercer, K. L., Crowley, D., and Jacks, T. (2002). ARF mutation accelerates pituitary tumor development in Rb+/- mice. Proc. Natl. Acad. Sci. USA, 99: 16865-16870.
  • Sharp, Z. D., Lee, W.-H., Nikitin, A. Yu., Flesken-Nikitin, A., Ikeno, Y., Reddick, R., Richardson, A. G., and Nelson J. F (2003). Minimal effects of dietary restriction on neuroendocrine carcinogenesis in Rb+/- mice. Carcinogenesis, 24: 179-183.
  • Connolly, D. C., Bao, R., Nikitin, A. Yu., Stephens, K. C., Poole, T., Hua, X., Hanahan, D., Vanderhyden, B., and Hamilton, T. C. (2003). Female mice chimeric for the expression of the SV40 TAg under control of the MISIIR promoter develop epithelial ovarian cancer. Cancer Res., 63: 1389-1397.
  • Zipfel, W. R., Williams, R. M., Christie, R., Nikitin, A. Yu., Hyman, B. T., and Webb, W. W. (2003). Live tissue intrinsic emission microscopy using multiphoton-excited fluorescence and second harmonic generation. Proc. Natl. Acad. Sci. USA, 100: 7075-7080.
  • Flesken-Nikitin, A., Choi, K.-C., Eng, J. P., Shmidt, E. N. and Nikitin, A. Yu. (2003). Induction of carcinogenesis by concurrent inactivation of p53 and Rb1 in the mouse ovarian surface epithelium. Cancer Res., 63: 3459-3463.
  • Manor, D., Shmidt, E. N., Budhu, A., Flesken-Nikitin, A., Zgola, M., Page, R., Nikitin, A. Yu., and Noy, N. (2003). Suppression of mammary tumor growth by cellular retinoic acid binding protein-II. Cancer Res., 63: 4426-4433.
  • Hamilton, T. C., Connolly, D. C., Nikitin A. Yu., Garson, K., and Vanderhyden, B. C. (2003) Translational research in ovarian cancer: a must. Int. J. Gynecol. Cancer, 2003 13 (Suppl 2): 220-230.
  • Shmidt, E. N., and Nikitin, A. Yu. (2004). Pathology of mouse models of human lung cancer. Comp. Medicine, 54: 23-26.
  • Nikitin, A. Yu. , Connolly, D. C., and Hamilton, T. C. (2004). Pathology of ovarian neoplasms in genetically modified mice. Comp. Medicine, 54: 26-28.
  • Nikitin, A. Yu. , Alcaraz, A., Anver, M., Bronson, R. T., Cardiff, R. D., Dixon, D., Fraire, A. E., Gabrielson, E. W., Gunning, W. T., Haines, D. C., Kaufman, M. H., Linnoila, I., Maronpot, R. R., Rabson, A. S., Reddick, R. L., Rehm, S., Rozengurt, N., Schuller, H. M., Shmidt, E. N., Travis, W. D., Ward, J. M., and Jacks, T. (2004). Classification of proliferative pulmonary lesions of the mouse: Recommendations of the Mouse Models of Human Cancers Consortium. Cancer Res., 64: 2307-2316.
  • Lin, S.-C. J, Lee, K.-F., Nikitin, A. Yu. , Hilsenbeck, S. G., Cardiff, R. D., Li, A. Kang, K.-W., Frank, S. A., Lee, W.-H., and Lee E. Y.-H. (2004). Somatic mutation of p53 leads to estrogen receptor a-positive and -negative mouse mammary tumors with high frequency of metastasis. Cancer Res. 64, 3525-3532.
  • Kurie, J. M., Minoo, P., Hecht, S.S., Nikitin, A. Yu. , and DeMayo, F.J. (2004). Lung cancer. In: Ed. Holland, E. C. Mouse Models of Human Cancer. Wiley-Liss. New Jersey. p. 83-102.
  • Flesken-Nikitin, A., Williams, R. M., Zipfel, W. R., Webb, W.W. and Nikitin, A. Yu. (2005). Use of multiphoton imaging for studying cell migration in the mouse. In: Ed. Guan, J.-L. Methods in Molecular Biology, vol. 294: Cell Migration: Developmental Methods and Protocols. Humana Press Inc., Totowa , NJ . p. 335 - 344.
  • Zhou, Z., Flesken-Nikitin, A., Levine, C. G., Shmidt, E. N., Eng, J. P., Nikitina, E. Yu., Spencer, D. M., and Nikitin, A. Yu. (2005). Suppression of melanotroph carcinogenesis leads to accelerated progression of pituitary anterior lobe tumors and medullary thyroid carcinomas in Rb+/- mice. Cancer Res. 65:787-796.
  • Nikitin, A. Yu., and Hamilton, T. C. (2005). Modeling ovarian cancer in the mouse. In: Ed. Mohan, R.M. Research Advances in Cancer. Global Research Network, Kerala, 49-59.
  • Kichina, J. V., Zeremski, M., Aris, L., Gurova, K. V., Walker, E., Franks, R., Nikitin, A. Yu. Kiyokawa, H., and Gudkov, A. V. (2006). Targeted disruption of the mouse ing1 locus results in reduced body size, hypersensitivity to radiation and elevated incidence of lymphomas. Oncogene 25:857-866.
  • Daikoku, T., Tranguch, S., Trofimova, I. N., Dinulescu, D. M., Jacks, T., Nikitin, A. Yu., Connolly, D. C., and Dey, S. K. (2006). Cyclooxygenase-1 is overexpressed in multiple genetically engineered mouse models of epithelial ovarian cancer. Cancer Res.66:2527-2531.
  • Zhou, Z., Flesken-Nikitin, A., Corney, D. C., Wang, W., Goodrich, D. W., Roy-Burman, P. and Nikitin, A. Yu. (2006). Synergy of p53 and Rb deficiency in a conditional mouse model for metastatic prostate cancer. Cancer Res. 66:7889-7898.
  • Cardiff, R. D., Anver, M. R., Boivin, G. P., Bosenberg, M. W., Maronpot, R. R., Molinolo, A. A., Nikitin, A. Yu., Rehg, J. E., Thomas, G. V., Russell, R. G., and Ward, J. M. (2006). Precancer in mice: Animal models used to understand, prevent, and treat human precancers. Tox. Pathology. 34:699-707, 2006.
  • Sundberg, J. P., Hackman, R. C., HogenEsch, H., Nikitin, A. Yu., and Ward, J. M. (2007). Training mouse pathologists: Five years of pathology of mouse models of human disease workshops. Tox. Pathology. 35:699-707.
  • Nikitin, A. Yu., Matoso, A., and Roy-Burman, P. (2007). Prostate stem cells and cancer. Histol. Histopathol. 22: 1043-1049.
CR_07
  • Zhou, Z., Flesken-Nikitin, A. and Nikitin, A. Yu. (2007). Prostate cancer associated with p53 and Rb deficiency arises from the stem/progenitor cell-enriched proximal region of prostatic ducts. Cancer Res. 67:5683-5690.
  • Barthold, S. W.,  Borowsky, A. D.,  Brayton, C., Bronson, R.,  Cardiff, R. D., Griffey, S. M.,  Ince, T. A., Nikitin, A. Yu., Sundberg, J., Valli, V. E., and Ward, J. M. (2007). From whence will they come? – A perspective on the acute shortage of pathologists in biomedical research. J. Vet. Diagnostic Invest. 19:455-456.
  • Liao, C.-P., Zhong, C., Saribekyan, G., Bading, J., Park, R., Conti, P. S., Moats, R.,  Berns, A., Shi, W., Zhou, Z., Nikitin, A. Yu., and Roy-Burman, P. (2007). Mouse models of prostate adenocarcinoma with capacity for monitoring spontaneous carcinogenesis by bioluminescence or fluorescence. Cancer Res. 67:7055-7546.
  • Corney, D. C., Flesken-Nikitin, A., Godwin, A. K., Wang, W. and Nikitin, A. Yu. (2007). MicroRNA-34b and -34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth. Cancer Res. 67:8433-8438.
  • Flesken-Nikitin, A., Toshkov, I.A., Nascar, J., Tyner, K. M., Williams, R. M., Zipfel, W. R., Giannelis, E., and Nikitin, A. Yu. (2007). Toxicity and biomedical imaging of layered nanohybrids in the mouse. Tox. Pathology 35: 804-810.
  • Choi, J., Burns, A. A., Williams, R. M., Zhou, Z., Flesken-Nikitin, A., Zipfel, R. W., Wiesner, U., and Nikitin, A. Yu. (2007). Core-shell silica nanoparticles as fluorescent biological labels for nanomedicine applications. J. Biomed. Optics 12: 064007.
  • Valli, T., Barthold, S. W., Ward, J. E., Brayton, C., Nikitin, A. Yu., Borowsky, A. D., Bronson, R. T., Cardiff, R. D., Sundberg, J., and Ince, T. (2007). Over 60% of NIH extramural funding involves animal-related research. Vet. Pathology 44: 962-963.
  • Matoso, A., Zhou, Z, Hayama, R., Flesken-Nikitin, A., and Nikitin, A. Yu. (2008). Cell lineage-specific genetic interactions between Men1 and Rb in neuroendocrine neoplasia. Carcinogenesis 29:620-628.
  • Xu, X., Page, J.L., Surtees, J.A., Liu, H., Lagedrost, S., Lu, Y., Bronson, R., Alani, E., Nikitin, A. Yu., and Weiss, R.S. (2008) Broad overexpression of ribonucleotide reductase genes in mice specifically induces lung neoplasms. Cancer Res. 68:2652-2660.
  • Antoch, M. P., Gorbacheva, V. Y., Vykhovanets, O., Toshkov, I. A., Kondratov, R. V.,  Kondratova, A. A., Lee, C., and Nikitin, A. Yu. (2008). Disruption of the circadian clock due to the Clock mutation has discrete effects on aging and carcinogenesis. Cell Cycle 7: 1197-1204.
  • Vias, M., Massie, C., E., East, P., Scott, H., Warren, A., Zhou, Z., Nikitin, A. Yu., Neal, D.E. and Mills, I. G. (2008). Pro-neural transcription factors as cancer markers. BMC Medical Genomics 2008, 1:17.
  • Schug, T. T., Berry, D. C., Toshkov, I. A., Cheng, L., Nikitin, A. Yu., and Noy, N. (2008). Overcoming retinoic acid-resistance of mammary carcinomas by diverting retinoic acid from PPARβ/δ to RAR. Proc. Natl. Acad. Sci. USA. 105:7546-7551.
  • Corney, D. C., Flesken-Nikitin, A., Choi, J. and Nikitin, A. Yu. (2008). Role of p53 and Rb in ovarian cancer. Adv Exp Med Biol. 622:99 -117.
  • Corney, D. C., and Nikitin, A. Yu. (2008). MicroRNA and ovarian cancer.  Histol. Histopathol. 23: 1161-1169.
  • Ince, T. A., Ward, J. M., Valli, V. E., Sgroi, D., Nikitin, A. Yu., Loda, M. F., Griffey, S. M., Crum, C. P., Crawford, J. M., Bronson, R. T., Brayton, C., and Cardiff, R. D. (2008). “Do-it-yourself (DIY) Pathology". Nature Biotechnology. 26:978-979.
  • Matoso, A., and Nikitin, A. Yu. (2008). Cancer stem cells in solid tumors. In Eds. Dittmar, T. and Zänker, K. S. Stem Cells and Cancer. Nova Science, New York. p. 87-110.
  • Nikitin, A. Yu., Nafus, M. G., Zhou, Z., Liao, C.-P., and Roy-Burman, P. (2009). Prostate stem cells and cancer in animals. In Eds. Bagley, R. G. and Teicher, B. A. Stem Cells and Cancer. Humana Press, p.199 - 216.
  • Cheng, L., Ramesh, A. V., Flesken-Nikitin, A., Choi, J. and Nikitin, A. Yu. (2010). Mouse models for cancer stem cell research. Tox. Pathology. 38: 62-71.
  • Nafus, M. G., and Nikitin, A. Yu. (2009). Cancer stem cells in solid tumours. In Eds. Dittmar, T. and Zänker, K. Stem Cell Biology in Health and Disease. Springer, Springer, Dordrecht, p. 295-326.
  • Kaufman M. H., Nikitin, A. Yu., and Sundberg, J. P. (2010). Histologic Basis of Mouse Endocrine System Development: A Comparative Analysis. CRC Press. Boca Raton, FL., 232 p.
  • Li, B., Antonyak, M. A., Druso, J. E., Cheng, L., Nikitin, A. Yu., and Cerione, R. A. (2010). EGF potentiated oncogenesis requires a tissue transglutaminase-dependent signaling pathway leading to Src activation. Proc. Natl. Acad. Sci. U S A. 107: 1408–1413.
    CR_07
  • Corney, D. C., Hwang, C., Matoso, A., Vogt, M., Flesken-Nikitin, A., Godwin, A. K., Kamat, A. A., Sood, A. K., Hermeking, H., , Ellenson, L., H., and Nikitin, A. Yu. (2010). Frequent downregulation of miR-34 family in human ovarian cancers. Clin. Cancer Res. 16: 1119–1128.
  • Liao,C.-P., Liang, M., Cohen, M. B., Flesken-Nikitin, A., Jeong, J. H., Nikitin, A. Yu., and Roy-Burman, P. (2010). Mouse prostate cancer cell lines established from primary and post-castration recurrent tumors. Hormones and Cancer. 1: 44-54.
  • Sarveswaran, S., Liroff, J., Zhou, Z., Nikitin, A. Yu., and Ghosh, J. (2010). Selenite triggers rapid transcriptional activation of p53, and p53-mediated apoptosis in prostate cancer cells: Implication for the treatment of early-stage prostate cancer. Int. J. Oncol. 36:1419-1428.
  • Williams, R. M., Flesken-Nikitin, A., Ellenson, L. H., Connolly, D. C., Hamilton, T. C., Nikitin, A. Yu., and Zipfel, W. R. (2010). Strategies for high resolution imaging of epithelial ovarian cancer by laparoscopic nonlinear microscopy. Translational Oncology. 3:181-194.
  • Cheng, L., Zhou, Z., Flesken-Nikitin, A., Toshkov, I. A., Wang, W., Camps, J., Ried, T. and Nikitin, A. Yu. (2010). Rb inactivation accelerates neoplastic growth and substitutes for recurrent amplification of cIAP1, cIAP2 and Yap1 in sporadic mammary carcinoma associated with p53 deficiency. Oncogene. doi:10.1038/onc.2010.300.
  • Liu, K., Cheng, L., Flesken-Nikitin, A., Huang, L., Nikitin, A. Yu., and Pauli, B. U. (2010). Conditional knockout of fibronectin abrogates mouse mammary gland lobulo-alveolar differentiation. Developmental Biology. doi:10.1016/j.ydbio.2010.07.001.